Everything You Must Know About AMPK Activators
AMPK is the regulator that is maintaining cellular energy homeostasis which is basically the foundation of the body’s functionality. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
In the body, the most important energy molecule that is present is ATP. To make it simpler, this is the point where cellular function starts. ATP breaks down into ADP that has less potential for energy since the cells are using energy. ADP is broken down to AMP containing the least energy potential among all 3. As a matter of fact, this is where AMPK becomes crucial by sensing if there is appropriate ratio among ATP/ADP/AMP and from there, tells the body if it requires more ADP to function properly.
There are different mechanisms in which AMPK acts on. This makes sense since AMPK is the master regulator of all functioning cells. AMPK activation has an impact on the body which depends on the balance of signaling pathways and factors. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – AMPK activation is gradually declining as we are aging. As a matter of fact, many experts believe that one factor that contributes to aging is AMPK. AMPK is important because it helps in having adequate level of new mitochondria and promotes cellular renewal as well.
Anti inflammation – it is interesting to know that AMPK activation helps in decreasing inflammation but this too can be decreased by inflammation.
Anti diabetic – as a matter of fact, AMPK is slowly becoming well understood in relation to its role in diabetes treatment primarily because of its capability to enhance insulin sensitivity.
There are lots of herbal products/constituents and nutritional products too that are proven to be effective as AMPK activator and few of these are:
Number 1. AICAR – this is AMP’s analog which is required for cellular use and storage similar to ATP. Because it is AMP’s analog, AICAR has the capability of stimulating AMPK’s activity directly which can actually boost muscle performance.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It has been shown to greatly boost insulin sensitivity in the body and carrying anti obesity effects.
Number 3. Green tea extract – this was actually discovered to help in activating AMPK by means of activating its upstream kinase.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.